Kappa Free Light Chain Disease

Light chain deposition disease lcdd is a rare condition characterized by the deposition of specific proteins monoclonal light chains in the kidneys and other organs light chains are used to make antibodies that the body needs to fight infection.

Kappa free light chain disease.

Higher levels of free light chains are another sign of developing disease. 65 of patients with myeloma have an igg type. Therefore the serum free light chain test is a better predictor of outcome than the amount of m protein in the blood. Renal pathologic spectrum in an autopsy series of patients with plasma cell dyscrasia.

Patients with this disease typically are over the age of 50 and have an average age of 67. The level of free light chains another kind of protein in your blood. The age at which you were diagnosed. The risk of developing light chain deposition varies significantly depending on the other disease that the patient has.

What are light chains. A free light chains test measures the amount of lambda and kappa free light chains in the blood. This means type g immunoglobulin one of the possible types of heavy chain one combination of types of light chain kappa or lambda. Lcs are normally cleared by the kidneys but in lcdd these light chain deposits damage organs and cause disease.

Light chain deposition disease nodular glomerulopathy kappa light chain deposition disease. If the amount of free light chains is higher or lower than normal it can mean you have a disorder of the plasma cells. The median survival from diagnosis was 30 mo for 52 patients with kappa lcd and 10 mo for 45 patients with lambda lcd p less than 0 0007. Light chain deposition usually occurs along with another disease affecting the whole body.

The kidneys are almost always affected and this often leads to kidney failure. The second most common type is the iga myeloma also in combination with any of the two light chains. This can be measured by the free light chain assay test on a blood specimen. Light chain deposition disease lcdd is a rare blood cell disease which is characterized by deposition of fragments of infection fighting immunoglobulins called light chains lcs in the body.

In general the higher the free light chains the more aggressive the disease is. These unlinked chains are known as free light chains. Ninety seven patients with light chain disease lcd were studied. Herrera ga joseph l gu x hough a barlogie b.

There are two types of light chains. Lambda and kappa light chains. There are two types of light chains. Igm ige and igd types have one much lower incidence.